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However, because the longer alkyl chain results in greater hydrophobicity, it was replaced by the ethylene glycol chain 25, 26. It remains unclear whether the 1,2,3-triazolyl ring, which enters the p -position of the phenyl group in UNI by a click reaction 27, of Abz-E2B is required trade and commercial broking services ltd the selective inhibition of CYP707A. Additionally, the click chemistry requires three steps (amination, azidation and click reaction), which was the leading cause of the low synthetic yield of Abz-E2B.

This should decrease the log P value to less than 4.

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